The Adverse Childhood Experiences study is one of the largest investigations ever conducted to assess associations between childhood maltreatment and later-life health and well-being. The ACE Study findings suggest that certain experiences are major risk factors for the leading causes of illness and death as well as poor quality of life in the United States. Building on the ideas shared at the 2014 Aspen ThinkXChange, this webinar explored how to more effectively address toxic stress in two-generation solutions and how other frameworks – like Strengthening Families – can play a role. Presenters included Ascend at the Aspen Institute and Ascend Network Partners Katie Albright (San Francisco Child Abuse Prevention Center); Jeannette Pai-Espinosa (The National Crittenton Foundation); and Jason Gortney (The Children’s Home Society of Washington State) in this important two-gen conversation.